Sleep low
Good advice from Tim.
I have gone to Quito from air level Both by bus and by airplane. Big difference when it goes slow.
One more: Try to avoid to sleep higher than needed.
Climbers say: Climb high, sleep low.
Ride over the passes, and try to get down again before bed time.
Well. Quito is in the bottom of a valley. So you do not find anything lower around. But you could use Quito as a base and do some trips.
E.g Chimborazo. And return to Quito for accommodation.
And avoid the challenge to sleep in the refugio on what is a base camp on Chimborazo. 4 800 m. Where the road ends. (Another one on 5 000 m. Walking up)
Watch this video. About sleeping at 4 895 m
https://www.youtube.com/watch?v=4x2i696-_2E
Drink a lot (not alcohol)and try to find some Coca leaves
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