Well, never say never but I suspect the reason why you don't see too many turbo'd four stroke singles is that their engine characteristics don't suit the way a turbo works.
You could probably make a reasonable go of fuel injection if you've got good engineering facilities, enough development time and a decent budget but apart from the satisfaction of doing it I'm not sure you'd gain a huge amount. It's obviously possible - most of the manufacturers have had to do it in the last decade or so.
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