Its really down to personal preference, I nearly bought a V Strom 650 for our South America trip and 2 up it would have been a much better bike than the DR650 we rode, but now using the DR solo for Canadian back country trips is way more fun than a V Strom. If you are riding unsealed roads its a great bike. The DR also crashes well, I have dropped and crashed mine more times than a hot potato - no fairings or expensive plastics, simple CV carb and it has a huge following in North America with lots of aftermarket parts. However, they do need a lot of aftermarket parts and upgrades to get them decent to ride, namely suspension work, seat, bigger tank etc.
The CB500X has a lower seat height and carries its weight well, it is also a lot smoother with the extra pot and EFI - better on the highway with a 6 speed gearbox and it has ABS, with a Rally Raid kit they will go 90% of where a DR will go. As Snakeboy says, the full RR kit is bloody expensive, almost the price of a used DR650!
Id suggest taking them both for a test ride - fin a Suzuki and Honda dealer event where they do test rides - or better still find someone locally with a modified DR and even a CB500X
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