Look it isn't "totally safe", as others have mentioned you get an escort on the Pakistan side, which is a PITA, but it is as safe as can be under the circumstances. We crossed Pakistan to China mid 18. Whilst we were in Pakistan two Chinese school teachers were abducted from Queta and murdered. So that I think demonstrates my point. However many do pass this way and it is nearly always incident free.
Perhaps your biggest problem will be getting a Pakistan visa. We know of a number of overlanders whom were denied their Pakistan visas as soon as Pakistan immigration discovered that they were coming from Iran.
Oh, two Czech girls were also kidnapped from Queta a couple of years ago and held hostage for 2 years. They were eventually released after their government payed a ransom. So shit does happen and you do need to be aware of it. take all reasonable precautions and you should be OK. Assuming of course you get your visas.
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