The seating position on a motorcycle puts a lot of weight on your bottom, in a way that's probably quite different to sitting on a normal chair. I think the major obstacle to overcome is getting used to spending large amounts of time sat on a motorcycle.
I've worked as a despatch rider for last two years, and I find if I go through a period of not doing too much motorway/distance work, those long distance runs start to give me a sore bottom. When I get back out on the motorways on a regular basis my bottom regains some of its hardiness again and the longer jobs no longer cause notable discomfort.
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