If I did the backpacking route, I would definitely rent bikes at various parts of the trip. I would probably have to give up the idea of exploring the stans, which I am a bit reluctant to do. I know that the visa and guides can be pricey through China, but I have read of people forming groups to make the cost more reasonable.
As for backpacks getting off the beaten path, you can get yourself enveloped in a culture and far away from any westerner pretty quickly with a backpack. If you find yourself always traveling in the well blazed tourist routes, that is by choice.
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