Only going to add that Ketchikan is landlocked (although you can ship there if you want), and nowhere near Vancouver. Prince George is far inland, but Prince Rupert is on the Alaska ferry route. However, last I checked stops here were infrequent at best, and it's 1500 km by road to Vancouver (as it happens, via Prince George). And the terminus of the Alaska ferry system is Bellingham, not Seattle.
Taking ferries in one direction is fine, but it's expensive and requires some advance planning, especially if you want a cabin or plan to get off and back on again at various ports.
Hope that's helpful.
Mark
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