I hope you will enjoy scooter "adv-riding" despite your health problems.
I think 250cc is the lowest level for engine size for a touring scooter (for 2).
I've travelled about 40k km on my scooter - Yamaha Majesty 250 - usually fully packed & with 2 people.
I did some trips on my YP 250 to Ukraine (Crimea), Turkey (close to Syrian border), Balkans, Central Europe etc with out serious problems. Up to nearly 10000 km during some trips.
Only high in the mountains (above 2600m) I had problems with low power engine (23HP) and luck of manual gear-box.
My usual travel speeds are up 95-105km/h (with 2 people and their "travel stuff") with a daily range about 1000km.
I don't think scooters are good for Himalayas Highway or the "Road of Bones", but for most european, northern arfica & asia countries scooters are OK for travel.
You just have to remember to take a 2nd v-belt with you! 
Scooter is just another motorbike with a huge - I mean HUGE - packing capabilities (200-300L of stuff on a scooter - no problem  )
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