I am colour blind so often green looks blue to me and I can't see red. I did notice what I would call brownish orange and on a white background it is relatively easy for me to read. Start mixing reds/blacks greens and blues and I wont even know there is writing present, so I wont compalin just not know I am not seeing it.

I used to manufacture and sell reading systems for the blind and visually impaired. There is a whole range of conditions out there. There is no one solution as to what is correct. On my systems for the visually impaired clients could choose a base font to any size. (limit a character had to greater than one pixel and less than a screenful). choose their own background and font colours (yellow on black was very common as a best choice). select the distance between characters and lines, also change the height to width ratio of the font.

So I know pleasing everyone will be impossible. But is is easy to antagonise more people with careful selection of gimmicky colours

I need a fairly big size of print so run a 22" at 1152 x 864 This is the highest resolution I can run and still read the text. I used to run at 1024x 768 but had to change up into what is not entirely comfortable for pages to format properly. I know there is stuff to the right of my screen at this moment, off the box into which I am typing. I never see that. so it was a waste of programming time. There was a time when a 17" screen gave me really legible print, but as the resolutions increase so I get to see less and less of what the developers are pushing out. It really is self defeating. Often I have to centre my screen to where the text is because of so much advertising clutter does not leave enough room for me to see the end of the text lines if i leave it left justified. Then I dont get to see the clutter at all.