UK-Kyrgyzstan and Safety
I would also add that I drove London-Bishkek (and on to Mongolia) last year in a school bus. Governments put out warnings consistently for nearly every country on earth. I would not want to drive much in Afghanistan or increasingly Iraq, but other than that I don't think there are many areas on your proposed route that you need to avoid. I was unable to secure an Iranian visa as an American citizen but may friends have gone through. Parts of NW Pakistan are dicey but it can still be done if you really want to.
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