I second the choice to going with a non spoke wheel and then in a pinch you can use any of the tire plugging stuff on the market to get a temporary fix.
On my Heritage ( with spokes ) I always had a concern with flats, similar to you. The HD's are heavy and they don't have a center stand, so you'd end up having to lay the bike on its side to effect a wheel removal.
There may also be some run flat tires that will fit your bike, you'll have to do some checking.
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1971 BMW R75 project,
2013 Suzuki DL650A
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