Did it recently and there were quite a few Mexicans and North Americans travelling through Central America on big expensive bikes, when we got down to Chile/Argentina there were loads - I mean loads. Mostly Brazilians and Argentinians, all brand new BMWs and Triumphs.
Just take normal precautions and check IOverlander for dodgy towns and areas.
BTW
Nearly every South American rider we met said they were riding to Alaska in 2024 so be prepared for heavy traffic
Enjoy
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