We never got to do the pamir last year, it was closed due to fighting. but we did get to ride the other road across Tajikistan and it was very beautiful.
try to get as many visas as you can before you leave. we had to get 2 in istanbul. Tajikistan was easy (dont catch that guy in a bad mood) but Uzbekistan took a week and was pricey. this can delay you a lot especially if time is a concern. Not sure about Kazakhstan, we got it in advance.
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