The road from puerto maldonado to Manaus is only 3 months a year realy passable (infos from a Colombian driver). As far as i know the best time is from July to September/oktober bevor rainseason jits in. I tryed to go but got stucket in cusco and by the time i was ready the rain fludded the street to brasil and i had to turn around in Puerto Maldonado. That was February 2015. There are boats to Manaus from puerto valeo if you can go there. They will take you a few days to Manaus.
Sorry that i cant help more.
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