There are apparently real differences between brands. I say apparently because I tend to run out, then grab whatever the local shop has on hand. With three pushbikes, each with a pair of tires of different ages and brands, I lose track of what I used where.
There are some fascinating text videos on Youtube if you want to start comparing. I liked one in which bike mechanics rudely puncture various tires with ice picks and screwdrivers, then measure how long it takes the sealant to stop all leakage. It's pretty impressive if you've been shut down by a little thorn or drywall screw.
Again, I've used sealants only in tubeless applications, but I'd say the main drawbacks involve weight--that's unsprung, rotating weight, which definitely matters when my weary legs are the source of power--and mess inside the tire when it needs attention. Plus expense, of course, but I rationalize that away glibly.
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