Unless badly rotted, rusty spokes/nipples/wheels can be cleaned up with work, if mostly surface rust. You'll need to evaluate the whole wheel, or have a pro do it if you're not sure.
Soak in WD40 (or other product), work hard with steel wool. It's labor intensive but works. Do INSIDE of the wheel rim as well, clean up spoke nibbles best you can.
Make sure to replace rubber rim strip on top of spoke nipples inside wheel .. (or use duct tape). Protects tube from spoke nipples sharp edges.
Yes, you can convert wheels to typeless-type by sealing spoke nipples with strong Marine type epoxy sealer. Usually this is done by Pro wheel specialist. Bit tricky to do correctly. (I tried it ... couldn't manage it.

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On a 250 Honda I would NOT recommend this. Not worth it, IMO.
First, it's an expensive process if you pay a pro. Second, it's not always reliable (leaks can happen) especially the front.
Woody's Wheel Works (USA) will NOT convert a front wheel ... too dangerous.
A front tube change is pretty EASY, no need to seal it. Run HD tubes, possibly run Slime or similar flat protection Goo. But Slime makes patching hard ... unless it's a Vulcanized patch (at tire repair shop) which sets tube on fire, melts patch onto tube. Permanent!
The fact is, older 250 Honda tire changes should be fast & easy. Good tire irons/tools is all you need, PRACTICE at home before Africa.
Carry at least 3 spare tubes, get them patched professionally if and when you can. (vulcanized patch is best) Sometimes a tube will be destroyed (this is why you need spares) ... so look after tubes. Learn to do proper patches when shops are not around. Quality tubes can be patched many times and still be usable.
If going off road in East Africa, good strong knobby tires probably best. Thick, stiff side walls are best with a tough carcass.
A few examples:
T63, IRC TR-8, MT21, Pirelli Rally, Dunlop D606 (many other options). About any knobby will fit if it's an 18" rear wheel?? A 17" ? more limited choices. Any 21"front will work. Carrying a spare rear tire is probably a good idea too. Front tire should last and last. Tarmac riding at high speed wears rear knobby fast.