I'd also say it's personal preference. Then again, the Africa Twin is a proven bike for long-term/long-distance stints – the F800 maybe not quite yet.
Couple of questions you should ask yourself maybe:
Weight?
Fuel consumption?
Weak points (check dedicated forms for those bikes)
My dream bike ever since the 90s WAS an Africa Twin. And in a way it still is. I nearly bought one for my RTW. But when I found a good one that was reasonably priced, the deal fell through. (Especially in Germany, the prices for ATs is incredibly high due to its 'cult' status).
I now got an F650 GS Dakar. Very happy with it, despite its weakpoints (waterpump, triple linkage/shock).
But a bullet-proof engine, just like the Africa Twin. And: the F650 weighs a lot less (still not light-weight though  and it uses a lot less petrol (which is not to be neglected – you'll save quite some money on fuel compared to carburetted bikes).
Generally, I'd say: two-up = two cylinders; one-up: single cylinder (don't ask why – maybe it's just me).
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