If considering the western BAM road (for me THE highlight of my trip to Magadan this summer) apart from the weight/poor suspension of a big bike being unsuitable for general terrain, a flat twin will NOT fit down the walkways on the railway bridges you'll have to negotiate to cross the very high/fast flowing rivers where the road bridges are destroyed by the weather or fires.
Only skinny singles (for mere mortals like me  ) or v twins (like a ktm 950... where you'll also have to be a very competent rider) will fit.
Basically any bike can ride pavement from Europe to Vladivostok or Magadan if you avoid interesting sections like western Mongolia, BAM and OSR. If it's muddy (like this year), even the NFR (referred to as the Federal Road by Walter, above) to Magadan will also end in a horror story on a shed like a big flat twin.
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