Me personally, although I would be in a car not on a bike, I would go from Calais to Luxembourg and then down to Lake Constance in Germany and then over the Alps into Northern Italy through the lakes and into or around Milan.
I really like Luxembourg, very nice old town that's on all different levels. Great place to stop for a day or so. Lake Constance is just gorgeous, I really like Friedrichshafen. There is a Zeppelin museum there and that's pretty interesting if you're into that sort of thing.
On your way over the Alps make sure you detour through Vaduz, just so you can say you've been to Lichtenstein
After Vaduz the roads and scenery get very interesting.
I'm actually rather jealous now, I'd love to do that journey again tomorrow if I could.
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