There have been some travel restrictions in Tibet, I don´t know, what the situation is right now. Even if you could go through there, expect the China part to cost big, big money. That kind of money goes a long, long way elsewhere in Asia.
Also all the way through Afghanistan is commonly considered a no-go, and most people go via Pakistan to Iran, or north to China and Kyrgyzstan (this route only has a small bit of China, so while still a PITA, should be much cheaper to arrange, than Laos->Nepal).
And you´re a seasoned traveller, the rest should be relatively easy, only traffic is horrible in some countries!
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