Took us two days in a car to Cannobio on Lake Maggiore some years ago. Our kids were primary school age at the time and fought each other all the way.
Fabulous area and loads to do but really narrow winding roads around the lake. Took about half a day to do the last 50 miles to the campsite we were staying at. The lake is fed from mountain streams so beware if you're thinking of swimming as the water is freezing!!
We went through Luxembourg and the German autobahns to Basel to avoid the French tolls and then slogged through Switzerland. Probably not the best route.
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