I'm sure you will continue to get conflicting reports about this topic. Rather than just put my opinion in, I've picked up some useful info from Health Canada's website, which also deals with the mefloquine (Lariam) debate.
"Malaria is a major killer worldwide and is the principal, life-threatening infectious disease that Canadian travellers face when travelling to high risk areas such as sub-Sahara Africa and New Guinea. In recent years, there has been a dramatic increase in malaria cases in Canadian travellers including several deaths.
For travellers to high risk areas, the risk of acquiring malaria and dying is significantly greater than the risk of experiencing a serious side-effect from
mefloquine. Over 11 million travellers have used mefloquine prophylaxis and severe reactions (seizure, psychosis) to this drug are rare (reported in 1 in 10,000 to 1 in 13,000 users). The great majority of mefloquine users (95-98%) have either no side effects or only mild or temporary ones. Occasionally a traveller will develop a less severe but still troublesome neuropsycho-
logical reaction (e.g., anxiety, mood change) to mefloquine (1 in 250 to 500 users) requiring a change to an alternate drug. These reactions are almost always reversible. However, death from malaria is not.
At the present time, for high risk regions of the world, mefloquine is the most effective drug to prevent malaria. Alternatives typically offered to travellers to Africa to prevent malaria are significantly less effective and often more toxic than mefloquine, i.e., chloroquine, proguanil (Paludrine), amodiaquine, pyrimethamine plus sulfadoxine (Fansidar), pyrimethamine plus dapsone (Maloprim). Doxycycline is an effective alternative but may occasionally have troublesome side effects and must be taken each and
every day in order to prevent malaria."
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Endorsed by the Canadian Infectious Diseases Society, Canadian Society for International Health, and the Canadian Public Health Association
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