I'm not an expert nor do I know what kind of route you are looking for? Hwy 15 that just goes south through Nogales and and down through Culican and down passes through states that have more warnings than others. (Mexico
) However, if you are traveling by the major road, I wouldn't worry about it. If you come across to Texas and down through Acuna and down 57 there is still some risk as there will be anywhere you travel. I think your chances are worse if you stay with the small roads, however that's where the fun stuff is too. I've traveled down there 8 or 9 times and I enjoy the smaller roads. i just try to be vigilant in my travels no matter where I'm at. If it doesn't feel right, keep on moving. As some of the more traveled folks will tell you, there are more risks in the road itself. Just use caution while riding as you normally would. (animals in the road, reckless and drunk driving, road deterioration, etc. etc)
The tollways are very expensive, so I would avoid as many as you can and try to avoid Mexico City and some of the larger ones.
I would probably take the scenic route if I had the chance. I've been to most of these places just not in this particular direction.
Cross at Aqua Prieta
Nuevo Casas Grandes
San Cristobol de las Casa or
Tapachula depending on where you'll cross borders
Have a great trip and we appreciate a report every now and then.