I'm about 13,000km into my trip with the DRZ. After the mods it is more comfortable than my F650GS.
I bought a windshield from Ceebaily, but ended up not using it because I realized I don't need a shield after my first test trip (1000 miles).
If you really enjoy riding fast on the highway then DRZ isn't the right bike. I have it geared up for highway cruising (SM gearing on S wheels) and it cruises OK at 100km/h. As far as wind, I haven't had a problem. Seat was a HUGE deal and isn't possible without my aftermarket replacement.
Check out the last couple of my blog listed in my sig, especially the one with the crappy photo the water crossing that is waist deep. W/o either exceptional riding skills or a light bike like the DRZ, I would not be able to explore such remote parts of the world. The guy I was riding with has a KTM 950 SE, which will do highway well and dirt well if you're a badass rider. I just want a bike that I can get the help of 2 other guys to lift onto a truck or boat.
I just hope my subframe holds together.. so far no problems