Tse-Tse is not a problem in West Africa - and even in Central Africa it's not that big a problem. I live now alreay quite a while here in Congo-Brazzaville and I can tell you that tse-tse flies have not been a problem... there's other problems ;-)
As to malaria, that's another story - after all it still is the biggest killer. On the other hand, I have had it now 5 times during the past 12 months and I'm still alive - most important is try not to get bitten (not always easy), take prophylaxis (although nothing works 100%), but most important, if you feel you are developing a fever, IMMEDIATELY try to see a doctor or take anti-malaria drugs (not the same as your prophylaxis though) to prevent it getting bad. If you treat it quickly it will probably be limited to feeling a couple of days really bad (sort of like being run over by a bus).
But no matter what, don't let that scare you away...