Only done this as part of a tour (on their bikes) but the road is rough, very, in places. Fuel is a problem, but there are places you can buy it - if you know where - local knowledge would be good.Not petrol stations.
You pass over the second highest pass in the world on the way, so, yes there may be altitude issues - some one who's done it on their own bike would better advice.
From memory there is one tented campsite you can stop at (possible to book ?) and another spot where you camp, but you can hire tents and porters who return to the above after your stay. (This if you haven't a tent)
The altituude is a definate problem for you, need to aclimatise by riding high camping low and building up to the height - Leh is high too. People that fly staright in often feel bad for a while.
Hope this helps.
It is absolutely fantastic - hope to do it on our trip if possible. If you get to Leh, see if you can find out how to get a pass for 'the worlds highest motorable road' forget name. Behind Leh.
Ladakh is stunning, absolutely stunning (unless you dno't like mountains !)