Either start with Istanbul via Greece border and TEM highway or first take a ferry to Cesme-Izmir from Italy (Brindisi) or from Aegean Islands and start from Western Anatolia.
A few suggestions:
2- All the way down from Istanbul down to Antalya either via Troy, Assos, Pergamon to Izmir or via Bursa, Bandirma, Gonen, Balya, Ivrindi, Allianoi, Pergamon, to Izmir and regions.
3- Two options from Izmir:
Ephesus - Priene - Denizli (Hierapolis) - Konya - Cappadocia
4- Ephesus - Priene - Heracleia (Bafa lake) - Bodrum (via ferry) Datca - Marmaris - Elmali - Antalya
5- Antalya - Mersin by the seashore (for motorcycling fun with curves and curves)
6- Mount Nemrut - Adapazari
7- Antakya (Antioch) - and even a daily trip to Halep (Aleppo) in Syria
8- Van lake and regions
9- Dogubeyazit / Ishakpasa palace
10- Black sea and inland Turkey: see Ride to Blacksea Coast of Turkey - Report - ADVrider
for a detailed report
11- Safranbolu (near Kastamonu)
12- Places like Goynuk (near Bilecik city for being far from the madding touristic crowd and hot weather in june/july.)
... and cold
in Izmir if you happen to pass by. Send PM for possible routes and details.