You're asking quite a lot there in just a weekend. Most of the wine producing areas are more southerly. But, for what it is worth, here are some ideas.
I would come into Le Havre rather than Calais. And then tack along the Seine river in the general direction of les Andelys (an old castle thing that makes a nice little stop). There are lots of lovely roads in this area.
I would then head to Cheyreuse via Rambouillet and Dreux on the D983 (pretty pretty road). Perhaps find a hotel around here.
You're then in shooting distance of Paris. How about a going in for the evening, when the streets are empty and the sun is low?
If you are after wine, then head east of Paris to the champagne region. They make a sparkling white that is quite popular.
Just some ideas. Best thing is to get a local road map when you arrive and look for the roads marked in green. They are always fine. Then take it as you please.
Simon, in Nantes, France.
Around the world 2000-2004, on a 1993 Honda Transalp