I normally split my stuff down into 3 areas
Me, all my cloths and needs. Cloths, normally at least 2 if not some extra changes of cloths, and a change of shoes. Some med stuff and other bits and bobs, food can be bought out, tent can be kept small, all sleeping stuff can be small etc etc. I find this area the easiest to change but all depends on money, more money less you travel with or more money the easier/small/lighter amount of load you carry.
Bike, this doesnt normally go up or down much. Simple tools that will change a wheel/tyre etc etc if its a massive job someone else can do it. Always try and make sure you have some sort of cover incase something happens
Travel, all the documents, information, cameras, bits and pieces you pick up along the way. Most of these are normally documents you need to bring so cant be left, and all the other bits are so small you dont notice them.